The CZ P-06 is a semi-automatic large-frame pistol chambered for .40 S&W. The P-06 is almost identical to the 75 P-01, a ubiquitous handgun used by the Czech National Police, except it has a different caliber.

The Model P-06 has a steel slide and an alloy steel frame both with a black polycoat finish. The barrel is hammer forged, meaning a tool was carefully passed through the bore to carve the rifled grooves. The P-06 features a 3-dot sighting system, and offers optional Tritium night sights.

According to CZ website, the 75P-01, on which the P-06 is modeled, is the only NATO spec pistol available to the public. During testing, the CZ P-01 averaged seven stoppages per 15,000 rounds fired.

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